Wednesday, October 30, 2019
Post-Keynesian and Austrian criticisms Essay Example | Topics and Well Written Essays - 1250 words
Post-Keynesian and Austrian criticisms - Essay Example The Neoclassical perspective of competition narrates the determination of prices, output and income distributions in markets via equality of supply and demand. This theory is based on three fundamental assumptions: 1. People have rational preferences defined over all variables that can be identified and associated with a value. Rationality in this context refers to the fact that each agentââ¬â¢s objective to operate in self-interest and maximize their individual benefits. This naturally leads on to the next assumption. Based on these assumptions, neoclassical theory of competition essentially is a doctrine that postulates the allocation of scare resources by firms to maximise profit which in turn, leads to a wide range of economic activity. Equilibrium is the result of individual optimization procedures. Utility maximization by consumers provides individual demand functions or correspondences which can be aggregated under certain assumptions to form the market demand function. Similarly, the market supply function is obtained from the optimization exercise by firms. The equality of these identifies the set of prices and quantities that are optima for producers and consumers alike and this is the competitive equilibrium. It should be convenient for future reference to note here that profit maximization requires a firmââ¬â¢s marginal cost is equal to its marginal revenue (MC=MR) since this corresponds to the maximum point on the total profit curve. Under perfect competition there are a very large number of firms in the market, each selling an identical product. Consequently, each firm caters only to an insignificant share of the market and is thus only a price taker. The profit maximization leads to P=MR=MC. There can be supernormal or positive profits only in the short run. In the long run, there is free entry and as a result, only zero profits can be sustained. In contrast, the monopolist can make positive profits both in the long run as well as the short
Monday, October 28, 2019
The Cycle of Nursing Theory Essay Example for Free
The Cycle of Nursing Theory Essay Nursing cannot exist without theory, and the concepts that define those principles. Every intervention a nurse organizes is based off of theory, and revolves directly around the patient. The current practice used as a Registered Nurse in the emergency room setting is similar, but less complicated than that of an Advanced Practice Nurse Practitioner. Emergency room nurses firstly ask the patient what their chief complaint is upon arrival. The chief complaint labels the patient, and gives them a triage level based on the amount of resources needed to intervene. The chief complaint (or illness) is the nurseââ¬â¢s focus of his/her practice. The nurse also takes into consideration the need to educate the patient and his or her own readiness to learn. All of these factors help reach the goal of making the patient ââ¬Å"feelâ⬠better and regain health. Below is a model of how nurses in the emergency room revolve directly around the patient. Figure 1.1: Emergency Room Registered Nurse Conceptual Framework Making the decision to use this framework of nursing and theory helps organize the nurse and prioritize his/her actions. Without knowing the chief complaint, the nurse cannot treat. Furthermore, the nurse must ask the patient the reasoning for his visit in the emergency room today. Often, patients have many symptoms regarding their illness; nurses must prioritize which symptoms are most concerning, and ask the patient what his bothering him/her the most (i.e. headache versus shortness of breath). After learning what the patient has arr ived for, the nurse must start gathering data that relates to the patientââ¬â¢s chief complaint. For example, if the patient presents with shortness of breath, it is important to gather data such as: oxygen saturation, respiratory rate and effort, lung auscultation, presence of cough, and observing patient color. In addition to objective data, it is important to gather subjective data. This type of data includes: patientà symptoms, health history, and social history (such as smoking). Next, the nurse will implement her plan of care and intervene by: providing supplemental oxygen, if needed, elevate head of bed, and encourage the patient to breathe slowly if breathing appears to be labored or fast. After each intervention, the nurse must reassess the patient to see if his/her interventions worked; if not, the plan of care must be changed to improve patient status. Subsequently, the nurse must take into account the need to educate the patient and his/her ability and readiness to learn. If a patient is not ready to learn, it makes it difficult to for the nurse to teach and help reach the overall goal of restoring health. This cycle continues each time the patient gets ill; the nurse always forms her plan of care around the patient. For example, if a patient is mentally handicapped, the nurse might direct her education towards the patientââ¬â¢s caregiver to ensure the patient has the greatest success of reaching health. This conceptual framework is applicable to emergency room nursesââ¬â¢ practice because it is a constant cycle, organized, direct, and patient-focused. In the emergency room setting, it is vital that nurses are able to prioritize and organize symptoms and data. If a nurse forgets to obtain an oxygen saturation (in the data section), this can be life-threatening to the shortness of breath patient! Furthermore, nursing interventions are always tailored around the initial chief complaint and data gathered. It is a cycle that starts over each time a patient presents with an illness. Even though this framework is frequently utilized, there are many areas in which it could improve. What about a patientââ¬â¢s environment, social stability, and bodyââ¬â¢s response to the illness? In addition, there are no interrelationships noted on this model. There are many ways this framework could improve, be more in depth, and help reach goals by learning about other nursing theories and theorists. Nursing theorist Myra Estrin Levine goes into great depth on the relationships between nurse and patient, and the holistic view on healthcare. Levine had many roles as a nurse and was well educated; additionally, her views on nursing are broad and theoretical. Levine defined ââ¬Å"three major concepts of the Conservation Model,â⬠including: ââ¬Å"(1) wholeness, (2) adaptation, and (3) con servationâ⬠(Alligood Tomey, 2010, p. 227). The current model shown in Figure 1.1 does not take into account the patient as a whole; it only takes into account particular partsà of the patient and current complaints/ailments. The current theory used by emergency room nurses (as explained above) could be greatly improved by understanding Levineââ¬â¢s major concepts, and how much environment alone can influence patients. This portion of the metaparadigm is defined as an ââ¬Å"organismic response;â⬠something nurses learn in anatomy and physiology classes, but often is forgotten when they begin practicing (Alligood Tomey, 2010, p. 228). This type of response is our autonomic nervous system telling the body to have a ââ¬Å"fight or flightâ⬠response. This fight or flight response to stress, illnesses, and a patientââ¬â¢s consciousness of what is happening around him/her can induce this response. Fight or flight can increase or decrease oneââ¬â¢s heart rate, blood pressure, anxiety, and/or stress. This response is different in all persons, and can vary greatly depending on a personââ¬â¢s previous experiences and if they feel a ââ¬Å"threat actually existsâ⬠(Alligood Tomey, 2010, p. 228). Other than the holistic approach to healthcare, Levine understood the importance of a nurse and patient relationship. Whether or not nurses and patients realize it, they are constantly util izing Levineââ¬â¢s conservation models. When taking care of several patients, nurses need to conserve on energy so that they do not get tired quickly. Often, things such as IV trays or kits are used to make it easier for nurses to conserve on energy (walk less) and complete tasks efficiently. In addition, when patients are sick, they must conserve on energy and rest so that the human body can fight off an illness. Conservations like this and of many different types are needed for both the nurse and patient. The conservation of structural integrity and personal integrity are utilized within each nurse and patient interaction. When a patient has a massive head trauma, for example, the nurse must keep his/her own personal integrity to protect the patient from increasing his/her own anxiety/stress; which would utilize more energy in the patient and decrease the bodyââ¬â¢s ability to heal. The nurse might be overcome with feelings when seeing a large amount of blood, but realizes that he/she must be well-informed of his/her non-verbal cues towards the patient. Personal integrity also includes the nurse putting importance on patient requests such as: do not resuscitate, HIPPA compliance, patient privacy, and educating the patient on procedures and interventions that are being done. With the head trauma patient, the nurse can maintain structural integrity byà holding pressure on the wound to prevent further blood loss. This type of nursing intervention can be life-saving, and prevent the patient from further deterioration. Conservation of energy, structural integrity, and personal integrity are crucial in all nursing interactions. Furthermore, it is the nurseââ¬â¢s responsibility to take into account and conserve social integrity as well. Society thrives on social well-being; additionally, Levine concluded that ââ¬Å"health is socially determinedâ⬠(Alligood Tomey, 2010, p. 229). When the nurse educates the patient in a fashion that makes the patient regain independence, this makes the patient increase personal integrity and become socially accepted in that he/she is regaining health. In society, people tend to define others by their illnesses. Whether it is cancer, obesity, limb amputation, or pregnancy, society will judge a person based on those health issues; moreover, the person will then be socially accepted or rejected. Part of the profession of a nurse is to help guide a patientââ¬â¢s family members and friends on how to perceive and react to that patient and his/her illness (youtube.com, 2011). Furthermore, it is important that the nurse improves a patientââ¬â¢s social integrity while in the hospital setting by proving social media and communication tools such as: magazines, television, newspapers, or telephone (University of the Philippines Open University [UPOU], 2011). This can help improve a patientââ¬â¢s self-estee m, and decrease the stress illnesses can create. Understanding the nurse-patient relationship and conservation models helps the nurse and patient succeed in regaining health within a patient. Simple models such as Figure 1.1 do not include the personal feelings of a patient or nurse, and how that can affect the overall result of a patientââ¬â¢s health/illness. Figure 1.2: Primary care nursing that utilizes Levineââ¬â¢s concepts of Conservation Model (Alligood and Tomey, 2010, p. 227) Levineââ¬â¢s conservation model explains what the primary care nurse has to take into account when assessing a patient (Fig 1.2). The nurse must base her care and decisions on the patient and his/her family. Figure 1.2 also helps explain the connection of a model to nursing metaparadigm; the well-being, person as a whole, education, and nursing aspects. In addition, seeing theà patient as a ââ¬Å"wholeâ⬠helps the primary care nurse remember to look at the patientââ¬â¢s overall health. This comprehensive assessment includes: clinical problems (body), psychological aspects (mind), and spiritual beliefs that may affect the plan of care. The interrelationships between wholeness, adaptation, and environment helps primary care nurses understand the bigger picture and how the advanced practice nurse can increase the outcome for the patient. ââ¬Å"Adaptationâ⬠describes the patientââ¬â¢s variables that can affect the patient as a whole, or be affected by his/her envir onment. For example, a patient may increase in age, quit smoking, or increase in weight; these variables and/or variations in a patient can greatly change the patient and/or treatments and interventions. A patientââ¬â¢s environment must be understood ââ¬Å"both internally and externallyâ⬠by the medical team (Alligood Tomey, 2010, p. 227). Again, this deals with the patient as a whole and is comparable to adaptation and a holistic plan of care. Knowing the environment that the patient resides in can affect his or her own health. If the patient doesnââ¬â¢t understand the notion that he/she is terminally ill, it may be difficult to explain the importance of a hospice program to the patient. Figure 1.3: Levineââ¬â¢s ââ¬Å"Conservation Principlesâ⬠and their interrelationships within a nurse and client connection (Alligood Tomey, 2010, p. 229). Levine also understood the nurse-patient relationship and how that can affect many areas within the ill-or-well patient. In this relationship, it is learned that nurses and patients often want to keep their integrity during any interaction. For example, a patientââ¬â¢s mother named Sarah brings her three-year-old daughter Claire in to the emergency room because Claire had a seizure at home. The patient is no longer having a seizure, and has been diagnosed with seizures over 1 year ago. Claire has a prescription for anti-seizure medicine, but her mother does not feel comfortable administering the medication; instead, Sarah brings Claire directly to the emergency room with each seizure occurrence. Now, Sarah is attempting to keep her own integrity by not having to administer anti-seizure medications in her daughterââ¬â¢s rectum in such a high stress situation. In addition, she wants Claireââ¬â¢s condition to be controlled in order for her to be accepted within the community. O n the other hand, the primary care nurseà practitioner must keep her personal integrity by not getting upset each time this patient visits the emergency room. It is the professionalââ¬â¢s responsibility to re-educate Sarah on the plan of care, or tailor it towards the individual and family. This would be an opportune time to discuss other options for anti-seizure medicines, education on how to administer the current medication available, and give a referral to a neurologist. When tailoring the plan of care, Levineââ¬â¢s four conservations come into effect (Fig 1.3). The patientââ¬â¢s energy is utilized with each seizure activity, and possibly structural integrityââ¬âdue to depletion of oxygenation to the brain and possible neuro deficits. The nurse tries to preserve personal integrity and educate the family of Claire in a way that is skilled and direct so that they may understand the concepts and accept the plan of care. Nursing interventions and education in situatio ns like this can be life-changing, and decrease stress for the patientââ¬â¢s family. It is important to remember that there are always assumptions made to any nursing model, but learning from that model is what is truly essential. Assumptions made to Levineââ¬â¢s conservation theory are that nursing interventions and implementation of those interventions can affect both the ill and/or well patient. Patients do not need to be ill in order to fit within the guidelines of conservation. Most patients feel compelled to be accepted, while maintaining personal authenticity (Fawcett, Schaefer, Moore, 1991). Moreover, the ââ¬Å"environmentâ⬠section of the model in Figure 1.2 can be falsely understood; that patients might only be able to learn in stress-free situations. Sometimes, stressful situation are where patients, families, and nurses learn best! Lastly, it appears that all human beings act in the same manner, and that patients and nurses alike utilize the same processes (UPOU, 2011). This cannot be true because all patients are diverse, and so are all nurses and primary care professionals. ââ¬Å"Nursing intervention must be founded not only on scientific knowledge, but specifically on recognition of t he individualââ¬â¢s behavioral responsesâ⬠(Cardwell, 2013). The response to nursing interventions and the ââ¬Å"trial and errorâ⬠processes are absent in the model (explained in Figure 1.2) of advanced practice nursing based on Levineââ¬â¢s theories. Advanced practice nurses are constantly intervening to improve the health and wellness of a patient; however, those interventions are not always successful. Furthermore, the advanced nurse practitionerà must modify her plan of care constantly. This type of framework of nursing is more of a cycle than a process. Holistic nursing is dedicated to the humanizing experience that the nurse can bring to the bedside, certain in her knowledge and skilled in her techniques, but sensitive and responsive to the person she finds there(Cardwell, 2013). In this phrase, Levine is summarizing the approach and goal of the advanced practice nurse practitioner. Advancing from the role of a registered nurse, primary care nurse practitioners increase their competence, knowledge, and skills. This increase in knowledge helps nurse practitioners in decision making, treatment options, and educating the patient. The primary function of the nurse practitioner is to educate patients across the lifespan, and help patients maintain health. Prevention is the best intervention. Since nurse practitioners begin their careers as bedside registered nurses, advanced nurse practitioners agree with Levineââ¬â¢s ââ¬Å"holistic approach to healthcareâ⬠and healing (Fawcett, Schaefer, Moore, 1991). In conclusion, primary care nurse practitioners can benefit from viewing the patient as a whole, while spending a large amount of time listening and educating the patient. No two patients, medical cases, or plan of care can be exactly the same. Nurse practitioners thrive because they spend time with their patients and getting to know their needs; this helps i ncrease patient success and healing. Nursing theory and the interrelationships between a patientââ¬â¢s conservation of energy, social integrity, structural integrity, and personal integrity are essential to the nurse practitioner. The increase of knowledge in the nurse practitioner helps him/her understand all aspects of the patient, and the most efficient way of approaching those patient needs. Levine once stated, ââ¬Å"Confront reality of environment, and maintain well-beingâ⬠(youtube.com, 2011) It is the purpose of a nurse practitioner to challenge the internal and external factors and environments distressing a patient, while providing resources and education to increase that patientââ¬â¢s health. The cycle and theories between nurses and patients will continue to transform and be challenged; it is the nurse practitionerââ¬â¢s role to put those theories into practice. References Alligood, M. R., Tomey, A. M. (2010). Nursing Theorists and Their Work (7th ed.). Retrieved from Cardwell, S. (2013). Copy of Myra Levine. Retrieved from http://prezi.com/uths961c5swr/copy-of-myra-levine/ Fawcett, J., Schaefer, Moore, K. (1991). Levineââ¬â¢s conservation model: a framework for nursing practice. Philadelphia: F.A. Davis Co. University of the Philippines Open University. (2011). Nursing Theories. Retrieved from http://nursingtheories.blogspot.com/2011_07_01_archive.html You Tube. (2011). The Nurse Theorists Myra Levine Promo. Retrieved from http://www.youtube.com/watch?v=C8tJUjDDKKw
Saturday, October 26, 2019
Influential Composers Of The Late 20th Century Essay -- Music Musical
Influential Composers Of The Late 20th Century Composersââ¬â¢ techniques matured throughout the 20th century, as did listenersââ¬â¢ ears.Thus, it becomes progressively harder to pinpoint influential musicians.One must distinguish between those simply continuing the modern tradition, and those truly breaking barriers. Robert Dick, dubbed ââ¬Å"Hendrix of the fluteâ⬠is one obvious boundary-breaker. (Dick)Born in New York City, Dickââ¬â¢s studies at the School for Music and Art were supplemented by lessons with acclaimed flutists Henry Zlotnik and Julius Baker.He attended Yale, receiving a B.A. in 1971 and a composition Masterââ¬â¢s in 1973. Dickââ¬â¢s most notable contribution to music is his revolution of the flute.He realized the fluteââ¬â¢s limited color palette and one-note-at-a-time capability was incompatible with ââ¬Å"an environment where the pace of change is acceleratingâ⬠¦The flute sound of the future will be yet more powerful and colorfulâ⬠¦Ã¢â¬ (Dick).Inspired by world music, jazz, rock, and electronic music, Dick made accessible the colorful extended technique spectrum: jet whistles, harmonics, throat tuning, multiphonics, whisper tones, circular breathing.Dick did not INVENT all these techniques.(Circular breathing has been a long-established traditionââ¬âespecially for Bulgarian kaval flutes and Rajasthanââ¬â¢s Narh flutes).But, it is through Dickââ¬â¢s advocacy that these techniques are becoming accepted practice.His tutorial method books have been hailed ââ¬Å"the definitive instructorâ⬠(Dick). Circular Breathing for the Flutist provides detailed analysis of the technique, visual aids, and step-by-step instruction that focuses on developing correct embouchure before applying more detailed coordination.After only 6 months of daily 10-15 minute practice, f... ...t to his/her time.Rent, the modern version of Pucciniââ¬â¢s La Boehme, unabashedly brings hush-hush issues of AIDS, drug addiction, and homosexual relationships to the forefront, without alienating audiences.He juxtaposes poignant melodies and clear harmonies with jarring subject matter and explosive characters that choose to revel in love, pain, and survival.Larsonââ¬â¢s contribution shows that being artistically cultured does not mean ignoring reality. Of the three New Yorkers mentioned, Copland was most influential.Without his pioneering music in the early half of the century, American music might never have established its own flavor.Without his advocacy of advancement in the second half of the century, techniques such as Robert Dickââ¬â¢s or Jonathan Larsonââ¬â¢s might not have had such a strong base on which to be established nor been accepted by ever-maturing audiences.
Thursday, October 24, 2019
Internet neutrality Essay
Internet neutrality enjoys a lot of support from consumers, technology companies and online companies. It is also supported by the main internet application organizations. This is mainly because they feel that the users of the internet should be in full unrestricted access to the internet applications and that they should have unregulated choice of the content they wish to view from the internet. The internet has applied the principle of neutrality ever since it was invented. An equal opportunity to access the internet is a basic concept that should be applied at all times, and thus no single user should be denied the right to access the internet. It would be not in order if the broad band carriers were allowed to use their power in the market to discriminate against the less powerful up coming carriers. The same way the telephone service providers are not allowed to dictate to the consumers whom they should call or even what to say in a telephone conversation, the same should apply to the broadband carriers, and thus they should not be permitted to misuse their power in the market to control online activities (Cerf, Para 7). Data would be controlled if internet neutrality is not allowed to continue, thus a legal mandate should be put in place to ensure that all the cable companies allow the providers of internet services unlimited access to the cable lines. Internet neutrality should be denied the right to screen, filter or interrupt the internet content unless permitted to do so by a court order. Internet neutrality should also ensure that there are laws governing digital freedoms and rights, thus the internet technology should remain open and free to all the internet users and this would enhance democratic communication (Zittrain, pp 78). Charging each and every website regardless of its market share would effectively hinder innovation and competition especially to the new small entrants into the market and thus more developments in technology would be blocked. By permitting preferential treatment of traffic in the internet, the newer and less competitive online companies would be highly disadvantaged and slow innovation would be realized in online services. In fact, most of the current major internet providers started as their operations in small garages with little capital and very great ideas, thus without internet neutrality such great ideas and innovations would never have been realized. If the internet neutrality is not maintained the internet would more or less appear like a television cable. It would be dominated by only a few companies who would be responsible of controlling the distribution and access of internet content. This would impact very negatively to some major industries and they would be faced with increased costs in order to acquire secure and fast internet facilities (Nuechterlein, & Weiser, pp 120) Conclusion The internet neutrality should be protected as it minimizes its control by the owners, it increases healthy competition and also gives others a chance to come up with innovative ideas which ushers in new technology every now and then and thus the internet remains relevant to the modern society. The neutrality of the network is very important in ensuring that a competitive and free market exists for the internet content. Work cited: Cerf, Vinton; Internet neutrality law needed (2006): Retrieved on 9th May from, http://www. infoworld. com/d/networking/internet-neutrality-law-needed-vi nton-cerf-says-577. Nuechterlein, Jonathan E. & Weiser, Philip J. ; Digital crossroads: American telecommunications policy in the internet age (2005): MIT Press, ISBN 0262140918. Zittrain, Jonathan; The future of the Internet and how to stop it (2008): Yale University Press, ISBN 0300124872.
Wednesday, October 23, 2019
Problem or Success of Implementing Tourism Essay
The problem that has face by the owner of the Salak Denai Chalet is promotion to promote their service. They only promote their service via customer, facebook and blog only. But, facebook and blog not actively yet. Besides, the chalet that they build was doesnââ¬â¢t have a plan and Majlis Daerah Yan was issued a summons to their business. Then, they had to spend a lot of money to hire the architect to draw plan to settle the problem with Majlis Daerah Yan. Besides, they have a lot of competition with other chalet around there that they was provided a better service and comfortable place to the customer. Sustainable and environmental affects towards project In every chalet at Salak Denai,its has their own pool. Only a river water of Batu Hampar that use to fill the pool. Besides, the owner of the chalet not use a chlorine to maintain the water cleaning. The owner of the chalet still preserve the natural condition of the forest. He always make sure that the area of surrounding was clean. The strength and success story of project The strength and success of project is Salak Denai has a five chalet with every chalet has their own pool. This success of project can was attracted the customer to rent the chalet. This chalet give more privacy to the customer when they want to picnic with their family.The owner of the chalet is more concern about the ââ¬Ëauratââ¬â¢ of the muslim and he was highlighted this project in his business. So, the customer do not have to worried anymore about the ââ¬Ëauratââ¬â¢ of their family because they get more privacy to swimming. This chalet become popular after he was organized his daughter wedding ceremony here. Now, every weekend and public holiday, this chalet was fully booked until March 2013. Only the weekday has no reservation from customer. Proposed new marketing plan As we know, this chalet was fully booked every weekend until March 2013. So, the owner must have a plan to build more chalet to accommodate the demand of the customer towards this chalet. In addition, the owner shall register the service with the minister of tourism so that all tourists can get information about the activities of Salak Denai chalet easily. Besides that ,owner must actively involve in the social network to promote the service The annual update about the info always like put pictures chalets along the information, update new-items added to the chalet and put the best service to compete with the newar chalets. How tourism can contribute to environmental conservation Salak Denai chalet use travel system which can preserve the natural condition such as using natural river water flowing into the pond in the chalet, built a house with the original wood from the trees and so on. Futhermore , owner of Salak Denai chalet not use substance can pollute the nature condition in that chalet area.
Tuesday, October 22, 2019
Messerschmitt Me 262 Used by the Luftwaffe
Messerschmitt Me 262 Used by the Luftwaffe Specifications (Me 262 A-1a) General Length: 34 ft. 9 in.Wingspan: 41 ft.Height: 11 ft. 6 in.Wing Area: 234 sq. ft.Empty Weight: 8,400 lbs.Loaded Weight: 15,720 lbs.Crew: 1 Performance Power Plant: 2 x Junkers Jumo 004B-1 turbojets, 8.8 kN (1,980 lbf) eachRange: 652 milesMax Speed: 541 mphCeiling: 37,565 ft. Armament Guns: 4 x 30 mm MK 108 cannonsBombs/Rockets: 2 x 550 lb. bombs (A-2a only), 24 x 2.2 in. R4M rockets Origins Though best remembered as a late-war weapon, the design of the Messerschmitt Me 262 began prior to World War II in April 1939. Spurred by the success of the Heinkel He 178, the worlds first true jet which flew in August 1939, the German leadership pressed for the new technology to be put to military use. Known as Projekt P.1065, work moved forward in response to a request from the Reichsluftfahrtministerium (RLM - Ministry of Aviation) for a jet fighter capable of at least 530 mph with a flight endurance of one hour. Design of the new aircraft was directed by Dr. Waldemar Voigt with oversight from Messerschmitts chief of development, Robert Lusser. In 1939 and 1940, Messerschmitt completed the initial design of the aircraft and began building prototypes to test the airframe. Design Development While the first designs called for the Me 262s engines to be mounted in the wing roots, issues with the power plants development saw them moved to pods on the wings.Ã Due to this change and the increased weight of the engines, the aircrafts wings were swept back to accommodate the new center of gravity. Overall development was slowed due to continued issues with the jet engines and administrative interference.Ã The former issue often was a result of the necessary high-temperature resistant alloys being unavailable while the latter saw notable figures such as Reichsmarschall Hermann GÃ ¶ring, Major General Adolf Galland, and Willy Messerschmitt all oppose the aircraft at different times for political and economic reasons. Additionally, the aircraft that would become the worlds first operational jet fighter received mixed support as many influential Luftwaffe officers who felt that the approaching conflict could be won by piston-engine aircraft, such as the Messerschmitt Bf 109, a lone. Originally possessing a conventional landing gear design, this was changed to a tricycle arrangement to improve control on the ground. On April 18, 1941, the prototype Me 262 V1 flew for the first time powered by a nose-mounted Junkers Jumo 210 engine turning a propeller. This use of a piston engine was the result of ongoing delays with the aircrafts intended twin BMW 003 turbojets. The Jumo 210 was retained on the prototype as a safety feature following the arrival of the BMW 003s. This proved fortuitous as both turbojets failed during their initial flight, forcing the pilot to land using the piston engine. Testing in this manner continued for over a year and it was not until July 18, 1942, that the Me 262 (Prototype V3) flew as pure jet. Streaking above Leipheim, Messerschmitt test pilot Fritz Wendels Me 262 beat the first Allied jet fighter, the Gloster Meteor, into the skies by about nine months. Though Messerschmitt had succeeded in out-pacing the Allies, its competitors at Heinkel had first flown their own prototype jet fighter, the He 280 the previous year.Ã Not backed by the Luftwaffe, the He 280 program would be terminated in 1943. As the Me 262 was refined, the BMW 003 engines were abandoned due to poor performance and replaced by the Junkers Jumo 004. Though an improvement, the early jet engines possessed incredibly short operational lives, typically lasting only 12-25 hours. Due to this issue, the early decision to move the engines from the wing roots into pods proved fortuitous. Faster than any Allied fighter, production of the Me 262 became a priority for the Luftwaffe. As a result of Allied bombing, production was distributed to small factories in German territory, with around 1,400 ultimately being bu ilt. Variants Entering service in April 1944, the Me 262 was used in two primary roles. The Me 262 A-1a Schwalbe (Swallow) was developed as a defensive interceptor while the Me 262 A-2a Sturmvogel (Stormbird) was created as a fighter-bomber. The Stormbird variant was designed at Hitlers insistence. While over a thousand Me 262s were produced, only around 200-250 ever made it to frontline squadrons due to shortages in fuel, pilots, and parts. The first unit to deploy the Me 262 was Erprobungskommando 262 in April 1944. Taken over by Major Walter Nowotny in July, it was renamed, Kommando Nowotny. Operational History Developing tactics for the new aircraft, Nowotnys men trained through the summer of 1944 and first saw action in August. His squadron was joined by others, however, only a few of the aircraft were available at any given time. On August 28, the first Me 262 was lost to enemy action when Major Joseph Myers and Second Lieutenant Manford Croy of the 78th Fighter Group shot one down while flying P-47 Thunderbolts. After limited use during the fall, the Luftwaffe created several new Me 262 formations in the early months of 1945. Among those becoming operational was Jagdverband 44 led by the famed Galland. A unit of select Luftwaffe pilots, JV 44 began flying in February 1945. With the activation of additional squadrons, the Luftwaffe was finally able to mount large Me 262 assaults on Allied bomber formations. One effort on March 18 saw 37 Me 262s strike a formation of 1,221 Allied bombers. In the fight, the Me 262s downed twelve bombers in exchange for four jets. While attacks such as this frequently proved successful, the relatively small number of available Me 262s limited their overall effect and the losses they inflicted generally represented a tiny percentage of the attacking force. Me 262 pilots developed several tactics for striking Allied bombers. Among methods preferred by pilots were diving and attacking with the Me 262s four 30mm cannons and approaching from a bombers side and firing R4M rockets at long range. In most cases, the Me 262s high speed made it nearly invulnerable to a bombers guns. To cope with the new German threat, the Allies developed a variety of anti-jet tactics. P-51 Mustang pilots quickly learned that the Me 262 was not as maneuverable as their own planes and found that they could attack the jet as it turned. As a practice, escorting fighters began flying high over the bombers so that they could quickly dive on German jets. Also, as the Me-262 required concrete runways, Allied leaders singled out jet bases for heavy bombing with the goal of destroying the aircraft on the ground and eliminating its infrastructure. The most proven method for dealing with the Me 262 was to attack it as it was taking off or landing. This was largely due to the jets poor performance at low speeds. To counter this, the Luftwaffe constructed large flak batteries along the approaches to their Me 262 bases. By wars end, the Me 262 had accounted for 509 claimed Allied kills against approximately 100 losses. It is also believed that a Me 262 flown by Oberleutnant Fritz Stehle scored the final aerial victory of the war for the Luftwaffe. Postwar With the end of hostilities in May 1945, the Allied powers scrambled to claim the remaining Me 262s. Studying the revolutionary aircraft, elements were subsequently incorporated into future fighters such as the F-86 Sabre and MiG-15. In the years after the war, Me 262s were used in high-speed testing. Though German production of the Me 262 ended with the conclusion of the war, the Czechoslovak government continued building the aircraft as the Avia S-92 and CS-92. These remained in service until 1951. Selected Sources Stormbirds: Me 262Me 262
Monday, October 21, 2019
Pond Weed Investigation essays
Pond Weed Investigation essays The effect of temperature on the rate of photosynthesis in Canadian Pondweed Elodea sp. In this investigation I plan to investigate how temperature effects the rate of photosynthesis in Canadian pond weed, this will be achieved by comparing the amount of oxygen produced by the pondweed at different temperatures. It will be a fair test and my only independent variable will be the different temperatures of water the pondweed will be submerged in. I am choosing different temperatures as my independent variable because I know from past experiments that different temperatures affect the enzyme activity and therefore the rate of photosynthesis. This experiment is also the most straightforward to set up and carry out, this means that extra time will be available to spend on repeats and extremely accurate results. All other factors of the experiment remain constant; the weight of pond weed, the light density, the colour of the light, the method of collecting the results (measuring the volume of displaced water in an upturned measuring tube) and the acclimation time of 2 minutes. The dependent variable is the volume of oxygen produced by the pondweed, this is measured by the amount of water displaced in an upturned measuring tube. The volume of oxygen produced is directly proportional to the rate o f photosynthesis, so having worked out the rate I can compare the different temperatures. First I will set up the apparatus, this consists of: a water bath at 20Ã °c, in this bath is a fermenting tube with the sample of pondweed inside and 20cm3 of water. The delivery tubing leads to another water container and to an upturned measuring tube. I leave the pondweed to photosynthesise for two minutes and then record the level of the water in the measuring tube, the pondweed is needed to be left for the two minute period to allow it to start functioning at the temperature. I then leave the pondweed to respire for three minutes, after this time I ...
Sunday, October 20, 2019
Luminescence Dating in Archaeology
Luminescence Dating in Archaeology Luminescence dating (including thermoluminescence and optically stimulated luminescence) is a type of dating methodology that measures the amount of light emitted from energy stored in certain rock types and derived soils to obtain an absolute date for a specific event that occurred in the past. The method is a direct dating technique, meaning that the amount of energy emitted is a direct result of the event being measured. Better still, unlike radiocarbon dating, the effect luminescence dating measures increases with time. As a result, there is no upper date limit set by the sensitivity of the method itself, although other factors may limit the methods feasibility. How Luminescence Dating Works Two forms of luminescence dating are used by archaeologists to date events in the past: thermoluminescence (TL) or thermally stimulated luminescence (TSL), which measures energy emitted after an object has been exposed to temperatures between 400 and 500à °C; and optically stimulated luminescence (OSL), which measures energy emitted after an object has been exposed to daylight. To put it simply, certain minerals (quartz, feldspar, and calcite), store energy from the sun at a known rate. This energy is lodged in the imperfect lattices of the minerals crystals. Heating these crystals (such as when a pottery vessel is fired or when rocks are heated) empties the stored energy, after which time the mineral begins absorbing energy again. TL dating is a matter of comparing the energy stored in a crystal to what ought to be there, thereby coming up with a date-of-last-heated. In the same way, more or less, OSL (optically stimulated luminescence) dating measures the last time an object was exposed to sunlight. Luminescence dating is good for between a few hundred to (at least) several hundred thousand years, making it much more useful than carbon dating. The Meaning of Luminescence The term luminescence refers to the energy emitted as light from minerals such as quartz and feldspar after theyve been exposed to an ionizing radiation of some sort. Minerals- and, in fact, everything on our planet- are exposed to cosmic radiation: luminescence dating takes advantage of the fact that certain minerals both collect and release energy from that radiation under specific conditions. Two forms of luminescence dating are used by archaeologists to date events in the past: thermoluminescence (TL) or thermally stimulated luminescence (TSL), which measures energy emitted after an object has been exposed to temperatures between 400 and 500à °C; and optically stimulated luminescence (OSL), which measures energy emitted after an object has been exposed to daylight. Crystalline rock types and soils collect energy from the radioactive decay of cosmic uranium, thorium, and potassium-40. Electrons from these substances get trapped in the minerals crystalline structure, and continuing exposure of the rocks to these elements over time leads to predictable increases in the number of electrons caught in the matrices. But when the rock is exposed to high enough levels of heat or light, that exposure causes vibrations in the mineral lattices and the trapped electrons are freed. The exposure to radioactive elements continues, and the minerals begin again storing free electrons in their structures. If you can measure the rate of acquisition of the stored energy, you can figure out how long it has been since the exposure happened. Materials of geological origin will have absorbed considerable quantities of radiation since their formation, so any human-caused exposure to heat or light will reset the luminescence clock considerably more recently than thatà since only the energy stored since the event will be recorded. Measuring Stored Energy The way you measure energy stored in an object that you expect has been exposed to heat or light in the pastà is to stimulate that object againà and measure the amount of energy released. The energy released by stimulating the crystals is expressed in light (luminescence). The intensity of blue, green or infrared light that is created when an object is stimulated is proportional to the number of electrons stored in the minerals structure and, in turn, those light units are converted to dose units. The equations used by scholars to determine the date when the last exposure happened are typically: Age total luminescence/annual rate of luminescence acquisition, orAge paleodose (De)/annual dose(DT) Where Deà is the laboratory beta dose that induces the same luminescence intensity in the sample emitted by the natural sample, and DTà is the annual dose rate comprised of several components of radiation that arise in the decay of natural radioactive elements. Datable Events and Objects Artifacts which can be dated using these methods includeà ceramics, burnedà lithics, burned bricks and soil fromà hearthsà (TL), and unburned stone surfaces that were exposed to light and then buried (OSL). Pottery: The most recent heating measured in pottery sherds is assumed to represent the manufacturing event; the signal arises from quartz or feldspar in the clay or other tempering additives. Although pottery vessels can be exposed to heat during cooking, cooking is never at sufficient levels to reset the luminescence clock. TL dating was used to determine the age ofà Indus Valleyà civilization occupations, which had proved resistant to radiocarbon dating, because of the local climate. Luminescence can also be used to determine the original firing temperature.Lithics: Raw material such as flints and cherts have been dated by TL; fire-cracked rock from hearths can also be dated by TL as long as they were fired to sufficiently high temperatures. The resetting mechanism is primarily heatedà and works on the assumption that the raw stone material was heat-treated during stone tool manufacture. However, heat treatment normally involves temperatures between 300 and 400à °C, not alw ays sufficiently high enough. The best success from TL dates on chipped stone artifacts likely are from events when they were deposited into a hearth and accidentally fired. Surfaces of buildings and walls: The buried elements of standing walls of archaeological ruins have been dated using optically stimulated luminescence; the derived date provides the age of burial of the surface. In other words, the OSL date on a foundation wall of a building is the last time that foundation was exposed to light before being used as the initial layers in a building, and hence when the building was first built.Others: Some success has been found dating objects such as bone tools, bricks, mortar, mounds, and agricultural terraces. Ancient slagà left from earlyà metal productionà have also been dated using TL, as well as absolute dating of kiln fragments or vitrified linings of furnaces and crucibles. Geologists have used OSL and TL to establish long, log chronologies of landscapes; luminescence dating is a powerful tool to help date sentiments dated to theà Quaternaryà and much earlier periods. History of the Science Thermoluminescence was first clearly described in a paper presented to the Royal Society (of Britain) in 1663, byà Robert Boyle, who described the effect in a diamond which had been warmed to body temperature. The possibility of making use of TL stored in a mineral or pottery sample was first proposed by chemistà Farrington Danielsà in the 1950s. During the 1960s and 70s, theà Oxford University Research Laboratory for Archaeology and History of Artà led in the development of TL as a method of dating archaeological materials. Sources Forman SL. 1989.à Applications and limitations of thermoluminescence to date quaternary sediments.à Quaternary Internationalà 1:47-59. Forman SL, Jackson ME, McCalpin J, and Maat P. 1988.à The potential of using thermoluminescence to date buried soils developed on colluvial and fluvial sediments from Utah and Colorado, U.S.A.: Preliminary results.à Quaternary Science Reviewsà 7(3-4):287-293. Fraser JA, and Price DM. 2013.à A thermoluminescence (TL) analysis of ceramics from Applied Clay Scienceà 82:24-30.cairns in Jordan: Using TL to integrate off-site features into regional chronologies.à Liritzis I, Singhvi AK, Feathers JK, Wagner GA, Kadereit A, Zacharais N, and Li S-H. 2013.à .Luminescence Dating in Archaeology, Anthropology, and Geoarchaeology: An Overviewà Cham: Springer. Seeley M-A. 1975.à Thermoluminescent dating in its application to archaeology: A review.à Journal of Archaeological Scienceà 2(1):17-43. Singhvi AK, and Mejdahl V. 1985.à Thermoluminescence dating of sediments.à Nuclear Tracks and Radiation Measurementsà 10(1-2):137-161. Wintle AG. 1990.à A review of current research on TL dating of loess.à Quaternary Science Reviewsà 9(4):385-397. Wintle AG, and Huntley DJ. 1982.à Thermoluminescence dating of sediments.à Quaternary Science Reviewsà 1(1):31-53.
Saturday, October 19, 2019
(Biochip Microfluidic Vortex Chamber) and (Biochip with Integrated Essay
(Biochip Microfluidic Vortex Chamber) and (Biochip with Integrated Vertical Emitting Light Source) - Essay Example The ââ¬Å"optical imaging technologyâ⬠(Bachman, 1986) was the best materials system of its time for fabricating ââ¬Å"photodiode arraysâ⬠(Bachman, 1986) that were used in NASAââ¬â¢s satellite system. Bachman considered this to be just the beginning of experimentation with microgravity for the production of semiconductors. He articulated the need for further advances in physics to improve the photoconductive properties of the detectors in order to improve the quality of the satelites Twenty years later Bachmanââ¬â¢s optical imaging device is being applied to identify diseases, as well as, analize the chemical and biological properties of different cystals and alloys in vortex chambers. The photoconductive device described in the study offers a cost effective method of fabricating biochips when coupled with simulation software known as Comsol software.Industries outside of quasi-government agencies such as NASA are utilizing microgravity technology. The budgets of these industries are not limitless, and therefore are in need of a feasible way of applying the quantum leap in semiconductor quality that is due to the microgravity science, without incurring the considerable costs that would keep them out of the field of biotechnology. The model described in this study offers theoretical outcomes when describing modified conditions calculated in simulation software as well as the actual observed events that occur within the various chambers of the photoconductive device. The properties that were observed utilizing simulated fluidic vortex chamber device are fluid flow, concentration and diffusion, and electrical conductivity. The conditions that were modified were velocity of fluid flow, locations of fluid concentration, and length of time the fluid would be concentrated at various locations. The results that the changing conditions as described in the ââ¬Å"incompressible Navier-Stoke equationâ⬠.
Friday, October 18, 2019
Green Grid Computing Essay Example | Topics and Well Written Essays - 500 words
Green Grid Computing - Essay Example Initially, The Green Grid has formed four initial technical working groups - Data Collection and Analysis, Data Center Technology and Strategy, Data Center Operations, and Data Center Metrics and Measurements - comprised of experts from the founding companies and open to others interested in participating. Other work groups may be developed as needs are identified. In addition, the group will engage with end-users in meaningful two-way dialog and work with other organizations, governmental bodies, and NGOs to provide a comprehensive and holistic view of data center energy efficiency (See: . The collective viewpoint of Green Grid members is that energy efficiency in the data center is the most significant issue facing technology providers and their customers today. This situation is not only due to exponential increases in power and cooling costs over the past few years, but also because customer demand for concentrated computing is outpacing the availability of clean reliable power in many places around the world. The Green Grid is the first industry initiative chartered to take a holistic view of the computing ecosystem, with a focus on addressing the pressing issues facing data center users (Green Consortium, Feb 2007). On the other hand, The Green Grid is an ambitious project to create a shared high-performance computing infrastructure for science and engineering at Dartmouth College. The Green Grid was created with the support of the Dean of the Faculty of Arts & Sciences to promote collaborative computing for the entire Dartmouth community.Ã
Investigation the Consumer Needs and Quality Marketing Essay
Investigation the Consumer Needs and Quality Marketing - Essay Example In order to meet consumer requirements and behavior, marketing research is conducted. Marketing Research helps to identify an appropriate marketing mix. Marketing Mix is actually the right combination of product, price, place, and promotion. Such research may either be formal or informal. Behavior that influences a consumer to prefer one brand over another is known as Consumer Behavior. It is all about the choices and preferences of a final consumer. McGraw-Hill/Irwin defined Consumer Behavior as The study of individuals, groups, or organizations and the processes they use to select, secure, use, and dispose of products, services, experiences, or ideas to satisfy needs and the impacts that these processes have on the consumer and society. Marketers use this knowledge to product design and price determination. Before making a purchase, consumers go through five stages of decision-making process such as; need recognition and problem awareness, information search, evaluation of alternatives, purchase, and post-purchase evaluation. First of all, the consumer recognizes his need. For example, a need for water in thirst. Then a consumer finds out the options available to meet his deprivation.
Thursday, October 17, 2019
Good and bad survey Research Paper Example | Topics and Well Written Essays - 750 words
Good and bad survey - Research Paper Example The survey questionnaire on Appendix II is also about a short product evaluation, seeking to obtain information as to how many people used the product, know its efficiency and convenience of its usage and some suggestions to improve it. The point of the work at hand is to evaluate these two sample surveys as to why one of them must be a good or bad survey, with important justifications coming from Chapter 6 and Chapter 8 of the text. The survey questionnaire in Appendix I consists of questions that are of varying data levels with corresponding scale. The most common are the nominal and ordinal scales. The good thing about using the ordinal scale in the question is that it avoids overlap in question options, allowing the marketer to thoroughly evaluate their product performance in the market. The use of nominal and ordinal scale in the questionnaire also prevents the proponent to come up with a bias reporting. In the first place, the choices given were able to suggest the prevailing opinion of the users or respondents and this means that not a hint coming from the proponent or research conductor could be found. For this reason, all of the questions stated in Appendix I can lead the proponent to get rid of probable bias and misleading the respondents. All the questions simply employ words that are not overstating the condition. They all not require the respondent to guess, because they absolutely want to dig up th e real opinion of the respondents without any hint of influence or bias coming from the research conductor. In addition, the survey questionnaire also uses an open-ended question that seeks to find out the exact information that should have to come from the respondents. The open-ended question is free from any hint of bias and even will lead to the determination of the exact information that the research conductor would want to find out. Regarding all of these bases, the survey questionnaire in Appendix I is a good
Synthesis Essay Example | Topics and Well Written Essays - 500 words - 3
Synthesis - Essay Example Sean needs to engage students in the topics by reducing the verbal instructions and communicating his instructions or lecture through visual aid. Hence, he should inter-mix verbal instructions with captivating visuals to help him gauge their attention. This would give Sean a clear understanding of studentââ¬â¢s knowledge regarding clay sculpting and what Sean needs to explain more. Students should start their own clay sculpture, but after fifteen minutes, students would be rotated and they would finish each otherââ¬â¢s sculpture. This kinesthetic movement would make his expectations clear, and would also be a fun activity for students to finish their friendââ¬â¢s work. He should also make a rule for students that if they break something, they would have to pay for it. Sara needs to first use the Socratic method of learning, ask students for information and then fill the gaps with her expertise. Sara is dealing with students who are passionate about football, but there are also girls in her class she needs to consider too. Sara needs to observe class behaviour, as well as community behaviour. In order to understand better her class and community, she should use visual aids, like pictures of legendary football players, monuments and places that the community thrives on. This would make her feel close to the class and the community, and would also make her more engaged with the students (Horwitz, 2010). Sara should hand out different tests to students, to further assess their knowledge; the tests for boys could be designed in a way that it includes questions relating to football. Similarly, she should use the girl preferred topics for the introduction of new concepts in her math lesson for girls, which interests them most. Megan would have a clear picture of her studentââ¬â¢s language capabilities, once she converse with them for some time. She should spend at least one week assessing their language capabilities by engaging them in
Wednesday, October 16, 2019
Good and bad survey Research Paper Example | Topics and Well Written Essays - 750 words
Good and bad survey - Research Paper Example The survey questionnaire on Appendix II is also about a short product evaluation, seeking to obtain information as to how many people used the product, know its efficiency and convenience of its usage and some suggestions to improve it. The point of the work at hand is to evaluate these two sample surveys as to why one of them must be a good or bad survey, with important justifications coming from Chapter 6 and Chapter 8 of the text. The survey questionnaire in Appendix I consists of questions that are of varying data levels with corresponding scale. The most common are the nominal and ordinal scales. The good thing about using the ordinal scale in the question is that it avoids overlap in question options, allowing the marketer to thoroughly evaluate their product performance in the market. The use of nominal and ordinal scale in the questionnaire also prevents the proponent to come up with a bias reporting. In the first place, the choices given were able to suggest the prevailing opinion of the users or respondents and this means that not a hint coming from the proponent or research conductor could be found. For this reason, all of the questions stated in Appendix I can lead the proponent to get rid of probable bias and misleading the respondents. All the questions simply employ words that are not overstating the condition. They all not require the respondent to guess, because they absolutely want to dig up th e real opinion of the respondents without any hint of influence or bias coming from the research conductor. In addition, the survey questionnaire also uses an open-ended question that seeks to find out the exact information that should have to come from the respondents. The open-ended question is free from any hint of bias and even will lead to the determination of the exact information that the research conductor would want to find out. Regarding all of these bases, the survey questionnaire in Appendix I is a good
Tuesday, October 15, 2019
Muste and the Logic of Christian Nonviolence Essay
Muste and the Logic of Christian Nonviolence - Essay Example Muste further argued that human beings are vulnerable to evil actions and inequities. Significantly, only an insignificant number is able to rebel inequities, and they do it rarely. However, he postulated that, for those who have cramped life, they have nothing noble for acquiescence, even the mere submission to a deity (Zinn, 1959). Argument It is worthwhile noting that; Muste has confessionary emphasized on the role of being upright in all endeavours. He has persuaded people to abide by right deeds and keep off the wrongdoers for each shall receive according to his efforts. Consequently, for one to engage, tolerate, or trade in pacifism he significantly not connected to passivism. Consequently, he has clearly provided a flourishing confessional approach on nonviolent confessions. Concisely, he has confessionary justified nonviolent revolutions by activists. Therefore, in a world based on violence, an individual must portray revolutionary aspects prior to pacifist qualities (Zinn, 1 959). Counter-argument My argument is that, based on a confessional approach, the author that Muste has not inspiring addressed the issue nonviolence. Significantly, he has demeaned those individuals who would feel sorry for their deeds and would wish to decline their evil lives. For instance, he has argued that the evildoers do not have a right to access superior forces. Therefore, he has implied that the righteous have an enhanced right of access to the deities. Concisely, Muste has confessionary, provided divergent insights on the nonviolence revolution, due to his incredible remarks on the fate of individuals who are acquiescent. Thesis statement Though A.J. Muste follows the logic of Christian nonviolence extremely carefully, the advantage of hindsight, this module explores the argument in pacifism as naive when adapted to the political realities of Musteââ¬â¢s time. Current research has revealed that, once the certain war is over the challenge, is always based on the victor . Significantly, the above crisis erupts from the friction where there is a problem to identify the agent of teaching the victor. Consequently, there is hardly any other way towards peaceful coexistence apart from the peace itself. Additionally, the current confessional approach on nonviolent revolution has revealed that human beings possess some indolence, which makes them not ready to accept disturbances. Therefore, they presume that, whenever there are no skirmishes or unrests, peace is also prevailing. Significantly, they often subconsciously prefer social peace, although it is merely apparent. The above scenario is engineered by their feeling of fear over the security of their lives, as well as, properties (Zinn, 1959). It is evident that disarming people is hardly possible and a war cannot be resolved unless there is a corporation of profound changes in the economy and the societyââ¬â¢s social arena. Significantly, human beings must denounce violent activities in accordance with existing systems. In addition, they must denounce evil activities such as material, as well as, spiritual evils. Accordingly, those who accept to denounce wealth and power, which is gotten from violent activities and puts a premium on acquisitiveness, by identifying themselves with the struggling masses, may significantly fight violence.
Monday, October 14, 2019
Extended commentary of The Convergence of the Twain by Thomas Hardy Essay Example for Free
Extended commentary of The Convergence of the Twain by Thomas Hardy Essay On the Title: Hardy uses two interesting words: ââ¬Ëconvergenceââ¬â¢ and ââ¬Ëtwainââ¬â¢. A convergence is a meeting of two paths, or entities ââ¬â in this case, a collision! ââ¬ËTwainââ¬â¢ is an archaic word for ââ¬Ëtwoââ¬â¢, i.e.; both the ââ¬ËTitanicââ¬â¢ and the iceberg. Such a title immediately positions the reader to the direction in which the poem will go. Hardy is not, as many elegiac poems of the day were, preparing to mourn the loss of the ship and the lives upon it but rather proceeding to examine the philosophical nature of the collision; perhaps it was fated? The other current use of ââ¬Å"twainâ⬠was in the pseudonym ââ¬Å"Mark Twain,â⬠made famous by the publication ââ¬â initially in England ââ¬â of ââ¬Å"The Adventures of Huckleberry Finnâ⬠in 1886. Clems adopted the nom de plume to suggest ââ¬Å"uncomfortable watersâ⬠or ââ¬Å"tight navigation,â⬠since two fathoms (ââ¬Å"twain,â⬠the sounding of a Mississippi deck-hand measuring the depth beneath the keel) would be dangerous for a steamboat. Background Information: The ocean liner ââ¬ËRMS Titanicââ¬â¢ famously sank, at two oââ¬â¢clock in the morning, upon the 15th April 1912. The disaster claimed 1,502 lives. Hardy was asked to write a poem to be read at a charity concert to raise funds in aid of the tragedy disaster fund. It was first published as part of the souvenir program for that event. Overall Structure: Hardy writes eleven regular triplet stanzas, with an AAA rhyme scheme throughout. The use of triplets allows for a more thorough exploration of ideas in each stanza; unified by the use of the rhyme scheme. Perhaps he also does this to create the effect of inevitability, for the rhymed words form their own paths coincident that lead to a preset conclusion ââ¬â the reader knows, that is, with which sound each stanza will end after he or she has only read the first line of that stanza. However, that knowledge only appears are having read the first few stanzas or so, echoing the idea that knowledge of those coincident paths of which the poem speaks is not always immediately discernible. Themes: The Vanity of Man, The Relationship between Man and Nature, Fate, Classical Entities. Difficult Language Notes: ââ¬Å"The Immanent Willâ⬠ââ¬â a force of fate. ââ¬Å"Salamandrineâ⬠ââ¬â associated with the salamander (a mythical creature) The poem runs in straight sets but I wish to divide in two for ease of analysis. ââ¬ËPart Iââ¬â¢ exists from Stanzas I to VI, whilst ââ¬ËPart IIââ¬â¢ takes the form of Stanzas VII to XII. Part I Notes: First Stanza Notes: Hardy introduces his poem in medias res ââ¬â the ship has been sunk and lies silently at the bottom of the ocean. He creates a calm effect over his poem through the consonance of the ââ¬Ësââ¬â¢ sounds: ââ¬Å"In a solitude of the sea Deep from human vanity, And the Pride of Life that planned her, stilly couches she.â⬠Particular elements of diction are worthy of note: * ââ¬Å"Deep from human vanityâ⬠ââ¬â this line points to the emerging theme of manââ¬â¢s failed vanity, in creating such a grand object to rule over the natural world, only to have Nature smite it. The phrase ââ¬Å"Pride of Lifeâ⬠accentuates this principle. Note how Hardy uses capital letters to make otherwise simple abstract nouns definitive. Although this is pre-emptive, I will now examine the theme of vaingloriousness (and point out notable pieces of evidence throughout the remainder of the poem) which Hardy presents. He uses irony to evoke the ridiculousness of mans plans. In stanzas I through to V, he juxtaposes images of the ships opulence, such as its mirrors meant / To glass the opulent and the shipââ¬â¢s gilded gear with images of the cold currents, ââ¬Å"sea-wormsâ⬠and moon-eyed fishes that now flow, crawl and swim through those former interiors. This creates a tangible image of the human vanity referred to in this first stanza; what people design for greatness ultimately ends up in a place of abasement. * ââ¬Å"Stillyâ⬠is a highly unusual adverb. Hardy uses it to create a sense of ââ¬Ëpeaceââ¬â¢. This is furthered by ââ¬Å"solitudeâ⬠and ââ¬Å"couchesâ⬠. ââ¬ËCouchesââ¬â¢ suggests restfulness, or an equanimity. S.L.S considers an image of a ââ¬Ëdeath bedââ¬â¢ upon the sea floor. Second Stanza Notes: Hardy focuses upon images of death and change in this stanza: ââ¬Å"Steel chambers, late the pyres Of her salamandrine fires Cold currents third, and turn to tidal rhythmic lyres.â⬠The furnaces of the ship, which contained the salamandrine fires of her engines (a form of LIFE), now have Cold currents thrid (note the a contrast in temperature ââ¬â and consequently, a contrast in living state) running through them. ââ¬ËThridââ¬â¢ itself is another reference to the title, as an archaic word for ââ¬Ëtwoââ¬â¢. Where there was once heat and life driving the engines of the ship, there is now coldness and death. A further juxtaposition within this second stanza is the use of the word pyreâ⬠, as it connotes funerals and death, while the use of salamandrine insinuates a certain tenacity for life (as salamanders were said to live through fires) that could be associated with the ââ¬ËUnsinkable Shipââ¬â¢ idea ââ¬â there was a theory prior to the sinking, now tragically ironic, that the Titanic was unable to sink. Yet, for all of the tragic (or formerly energetic, given the nature of fire) nature of the ship, Hardy once again returns to ideas of peace and harmony. ââ¬Å"Rhythmic tidal lyresâ⬠are reminiscent of the classical entities ââ¬â such as Apolloââ¬â¢s lyre and his place in Arcadia ââ¬â and consequently calming images. The distinct iambic meter in this phrase aids the calming lilt of the lines. Hardy presents the Titanicââ¬â¢s corpse in a peaceful light, however chilling and panicked her death. Third and Fourth Stanza Notes: I have above described the idea of vanity. I will pick out key phrases from these stanzas which support this idea ââ¬â their key point is to achieve the above: * ââ¬Å"mirrors meant to glass the opulentâ⬠CONTRASTED TO ââ¬Å"grotesque, slimed, dumb, indifferentâ⬠sea worms. Note the cruelty and emphasis on ââ¬Å"indifferentâ⬠. * ââ¬Å"Jewels in joy designedâ⬠CONTRASTED TO ââ¬Å"lie lightless, all their sparkles bleared and black and blindâ⬠Note the use of polysyndeton. * ââ¬Å"gilded gearâ⬠. Note alliteration. Fifth and Sixth Stanzas: Thus far Hardy has thoroughly examined the idea of vanity and the sunken ship itself. At stanza VI, Hardy changes his focus to the process by which the ship sank, in reference to Hardyââ¬â¢s ââ¬Ëquestionââ¬â¢ formulated in stanza V. V ââ¬Å"Dim moon-eyed fishes near Gaze at the gilded gear And query: ââ¬ËWhat does this vaingloriousness down here? VI Well: while was fashioning This creature of cleaving wing, The Immanent Will that stirs and urges everythingâ⬠It is obvious that Hardy engineers the explanation of the collision as a response to the ââ¬Å"fishesââ¬â¢Ã¢â¬ question ââ¬â although one would initially expect the final line of stanza V to be rhetorical. Before diverging upon the analysis of Hardyââ¬â¢s response, note some key elements of this stanza: * ââ¬Å"moon-eyedâ⬠(white and dull) contrasts with the shiny, golden nature of the ââ¬Å"gildedâ⬠. This accentuates the differences between the metallic (man-made) ship and the natural world. Also note the alliteration used in this line. Question why? * In an final assault on the vanitas vanitatum, observe that Hardy utilises anthropomorphisation to allow even the fish to question Manââ¬â¢s will in creating such ââ¬Ëvaingloriousnessââ¬â¢ ââ¬â a Natural force (perhaps a personification of Nature itself?) labels the ship a vanity. What consequence does this have? This query, although appearing rhetorical, is answered by Hardy. Denoted by the use of ââ¬ËWellââ¬â¢, he switches to a colloquial register ââ¬â this again adds to the sense of a Volta at stanza VI. Also note the sudden introduction of prominent enjambment at the end of the poem. The sense of stanza VI rolls into the VIIth, in direct opposition to the previous use of ââ¬Ëpoetic closureââ¬â¢ to end all previous stanzas ââ¬â Hardy normally uses a form of punctuation. Now itââ¬â¢s gone. Apart from being a ââ¬Ëchangeââ¬â¢ in its innate self, the enjambment aids in increasing the pace of the poem. This is highly significant. Seeing as, from this point forth, Hardy creates a ââ¬Ëconvergence of the twainââ¬â¢ within the poem itself ââ¬â i.e.: he brings the two entities together (I will later explore this process in detail) from obscurity to the point of their collision ââ¬â then increasing the pace at which the two entities move (which is obviously determined by the pace of the poem) must bring them together faster. This adds to the sense of movement, of fast movement and of dramatic effect. Well done, Mr. Hardy. Note some language details: ââ¬Å"Creature of cleaving wingâ⬠is a very interesting phrase. ââ¬Å"Cleavingâ⬠has multiple meanings, all of which are appropriate to Hardyââ¬â¢s imagery. Primarily, he may be imagining the ship as it ââ¬Ëcleavesââ¬â¢ through the water, as all good ships should do. Remember, in its day the Titanic was the fastest liner afloat. ââ¬Å"The cleaving wingâ⬠may therefore be the iron bow of the boat. Notice how Hardy is utilising additional anthropomorphisation, in referring to the ship as both a ââ¬Å"creatureâ⬠and one with ââ¬Å"wing[s]â⬠. The iceberg, however, remains inanimate. I doubt that there are any really deliberate poetic techniques to be synthesized from this but perhaps Hardy encourages a larger empathic response from the animate ship than from the inanimate iceberg? However, we must also acknowledge the metallic ââ¬Å"knife-likeâ⬠associations with ââ¬Ëcleavingââ¬â¢ ââ¬â like ââ¬Ëcleaverââ¬â¢. This has a highly inanimate connotation. [Another weak point, acknowledged.] There also exists an archaic definition in the verb ââ¬Ëto cleaveââ¬â¢ ââ¬â as in a Biblical usage ââ¬â meaning ââ¬Ëto join in matrimonyââ¬â¢. This is of enormous interest. Hardy later plays a great deal upon the idea of the twain being marital (and even sexual) mates. Throughout the poem he refers to them with terms connotating a ââ¬Å"confirmed relationshipâ⬠. We may be ââ¬Å"reading intoâ⬠the phrase a little too deeply but it is a comment worthy of note. Perhaps Hardy is using the archaic definition of the verb to further advance his marital imagery? He is certainly no stranger to using such odd vocabulary; observe ââ¬Å"The Darkling Thrushâ⬠! Finally, I wish to examine ââ¬ËThe Immanent Willââ¬â¢. ââ¬Å"Immanentâ⬠is not an archaic spelling of ââ¬Å"imminentâ⬠ââ¬â do not get confused in terms of these different words! ââ¬Å"The Immanent Willâ⬠is somewhat comparable, in terms of a philosophical idea, to the Christian concept of the ââ¬Å"Holy Spiritâ⬠or ââ¬Å"Holy Ghostâ⬠. It is a spiritual, but existent, entity within every object which determines its fate or actions. Christianity has branches ââ¬â notably in Catholicism ââ¬â which believe in a pre-determined plan, of Godââ¬â¢s design. In other words, we are all on a plan set out by God. The Holy Spirit helps us to achieve what God wishes; it provides inner strength and resolve. Hardy did not have an easy relationship with religion; born a Christian, he went through multiple tumultuous periods of atheistic belief. Thatââ¬â¢s probably why he hasnââ¬â¢t gone and just written; ââ¬Å"God, or some deified entity, has allowed and planned for the demise of this here ship. And thatââ¬â¢s why the iceberg, which could have been anywhere in a 3,000 mile radius of the vast Atlantic Ocean, just so happened to strike the ship. Deal with it.â⬠So, instead, he has substituted a strictly non-religious term to his idea of Fate. Indeed, he later refers to the Classical ââ¬ËFateââ¬â¢ entities to again replace any otherwise religious terminology. Remember also that Hardy is not aiming to criticise Christianity in a poem intended to raise money for the victimsââ¬â¢ families. Thus, clear religious controversy was not a good idea. Stanzas VIII and IX Notes: ââ¬Å"And as the smart ship grew In stature, grace and hue, In shadowy silent distance grew the iceberg too. Alien they seemed to be: No mortal eye could see The intimate welding of the later history,â⬠Again, Hardy invites further comparison through the use of juxtaposition; he now places the two entities in a relative time scale. The use of the word ââ¬Ëasââ¬â¢ creates this effect, as it brings almost a simile-esque comparative sense to the stanzas. We must focus on the idea of the twain ââ¬Ëgrowingââ¬â¢ ââ¬â as that is the image which Hardy evokes ââ¬â and the way in which both are joint in the use of the same verb. The obvious mental image is one of a familial relationship; they grow simultaneously but are fatally unaware of each other. Indeed, the distance between them is made explicitly clear and further emphasized by the alliteration used with ââ¬Å"shadowyâ⬠and ââ¬Å"silentâ⬠. Observe, in the phrase ââ¬Å"In stature, grace and hueâ⬠, Hardy returns to the original theme of the shipââ¬â¢s grandeur. He appears, in this occurrence, to be rather more commending (or perhaps simply more mournful) of the ship and its purpose. Stanza IX further dwells upon the notion of fate. Indeed, Hardy utilises some more imagery worthy of note, full of oxymorons. ââ¬Å"The intimate welding of the later historyâ⬠It takes little to see that this further advances the ideas of both the twainââ¬â¢s ââ¬Ëmarital intimacyââ¬â¢, of the metal-related imagery associated with the ship, but also, in the final few words, the idea of Fate. If one can know, in the present, the details of the futureââ¬â¢s past ââ¬â in other words, the near future ââ¬â then surely one is saying in an oddly convoluted way that a certain action is destined to soon take place? Itââ¬â¢s an oxymoronic (ââ¬Å"later historyâ⬠is oxymoronic in my book!) way of saying the same as before; the twain are destined to collide. Stanzas X and XI Notes: ââ¬Å"Or sign that they were bent By paths coincident On being anon twin halves of one august event, Till the Spinner of the Years Said ââ¬ËNow!ââ¬â¢ And each one hears, And consummation comes, and jars two hemispheres. Very little needs to be said about the action in these stanza. The Twain collide, bringing together the long wait in both metaphorical and poetic terms. Hardyââ¬â¢s precise choice of words and imagery is somewhat more interesting, however. For example: * ââ¬Å"Paths coincidentâ⬠does not point to a coincidence, as one might initially assume, but rather to a ââ¬Å"co-incidentâ⬠(i.e. ââ¬Å"togetherâ⬠) act. The Twain are, on reflection, on a course which emulates two graphical lines, in the way that they bisect. Does this then also reflect a sense of Fated entity? Graphical lines do not change, thus their ââ¬Ëcollisionââ¬â¢ is determined and sealed. * ââ¬Å"Twin halves of one august eventâ⬠reminds the reader of the action and precise existence of the collision. In the end, the act was a very physical, not philosophical one. Hardy acknowledges this, but attempts to draw out the unified nature of the Twain, in the intrinsic act of their collision. Note that the usual use of ââ¬Å"augustâ⬠to mean ââ¬Å"awe inspiring or admiration; majesticâ⬠is not intended by Hardy here in a positive way. He merely wishes to express wonder at the grand, if tragic, culmination of two great forces. And yes, it is rather melodramatic. * Hardy at lasts then returns to his Fated theme with the phrase ââ¬Å"The Spinner of the Yearsâ⬠. Reminiscent of the Classical Greek Moirai or the Roman Parcae (three old hags who would run, spin and cut the threads of life), Hardy refers to the middle of the three ââ¬â the Spinner. Spinning a mortal thread has always occupied a position in mythology. Hardy utilises it to draw out a sense of fate. Fate itself conducts the affair, it seems, given that the Twain act upon the word ââ¬Å"Now!â⬠to converge. * Emerson Brown, scholar of medieval literature, pointed out that the poem is 33 lines long, whilst line 33 echoes the 33-year-old Christââ¬â¢s last words: ââ¬Å"consummatum est.â⬠In any case, when ââ¬Å"consummation comesâ⬠, Thomas Hardy sends 1,500 souls to the bottom with an obscene pun. To ââ¬Å"comeâ⬠has borne a sexual connotation since the 17th century, at least, while consummation traditionally means the fulfilment of the marriage contract by intercourse. The image of the ââ¬ËTitanicââ¬â¢ and the iceberg copulating is hard to take seriously ââ¬â therefore we must question whether Hardy truly intends it. Nevertheless, it advances the idea of the twain existing in a marital bond. Note the sudden use of speech, in the present tense. Very dramatic. Brings the Twain together in Time for the last time!
Sunday, October 13, 2019
Use of Protease Inhibitors as Insecticides
Use of Protease Inhibitors as Insecticides The Plagues of Egypt are a well-known to many, to send a message to the Pharaoh, the eighth of which saw Moses have God send was a plague of locusts to destroy crops. Luckily those were mere allegorical stories. What is true is that crop yields for ancient societies have always been plagued pests destroying crops. Even in modern times pests are a major issue for farmers. Effective modern delivery methods of insecticides to fight pests such as chemical sprays like the infamous roundup by Monsanto have proven to be effective, but face issues such as potential poisons lingering in the environment, insects acquiring resistance to them over time, not being very specific in their targets often killing everything they are sprayed on, and tend to be quite toxic. A more effective method has been the use of biological pesticides, where plants in question generate toxins required to fight insects specifically without being toxic. One methods of delivery that has shown promise has been to use pr oteinase inhibitors. Proteases are found in almost all organisms playing important roles in biological processes by breaking down proteins via hydrolytic reactions (Lin et al., 2017). If proteases are overexpressed in a cell it can lead to many proteins being degraded needlessly affecting cell function (Lin et al., 2017). As a result, proteases need to be properly controlled and one of the most efficient ways to do so is with protease inhibitors. When proteinase inhibitors (PIs) bind to digestive enzymes it causes them to become unreactive (Broadway and Duffey, 1986). The pancreas would then have to secrete additional proteinases itself to fight the inhibition from inhibitors so that normal digestion can occur and prevent re-absorption of protease-inhibitor enzyme complex (Broadway and Duffey, 1986). If this process is left unhindered it would lead to loss of essential amino acids which could have be used to build more proteases (Broadway and Duffey, 1986). This loss of amino acids results in an amino ac id deficiency that leads to growth, development and survival issues of the organism (Fatemeh and Bandani, 2011). What makes proteinase inhibitors attractive for controlling pests is that they are encoded by single genes and are effective over wide ranges of pests, making them more practical than methods that rely on inhibiting complex pathways with similar targets (Fatemeh and Bandani, 2011). A substantial amount of development has gone towards finding suitable proteinase inhibitors for plants to express. Insects have also been found to be adapting against the use of protease inhibitors, with some being able to overexpress gut proteases or create new enzymes that are harder to inhibit (Nath et al., 2015). This only shows that the study of proteinase inhibitors still has a long ways to go and will require much more study. Some of the techniques studied in recent years to deter pests include use of trypsin inhibitor against lepidopteran larvae and serine proteinase inhibitors against mosquitos. It was believed that a trypsin inhibitor that was expressed in the germinating seed of Dolichos biflorus would be effective the gut proteins of P. brassicae and S. littoralis. To test this theory researchers extracted the PI from germinating various seed samples then sterilizing seeds in ethanol and water and growing them, collecting the plant seeds from flowering plants at different time intervals and then grinded them up into fine powder and processed it with acetone to get a crude extract (Nath et al., 2015). Researchers were able to measure and extract the amount of trypsin inhibitor in each seed from the crude extract via centrifugation and found that the more days after germination when they extracted the trypsin inhibitor the less the seed had (Nath et al., 2015). This decline coincided with noted decreases in soluble protein activity in the seeds after germination which could be attributed to degradation of proteins including inhibitors and proteases during germination (Nath et al., 2015). To measure trypsin inhibitor effectiveness against gut proteases of organisms, researchers also dissected the midgut of P. brassicae and S. littoralis and centrifuged it to isolate for a source of trypsin, which they found (Nath et al., 2015). To measure activity of inhibitor against gut proteases, researchers measured optical density after mixing inhibitor and gut proteases together (Nath et al., 2015). It was found in this study that all trypsin inhibitors extracted from seeds exhibited inhibitory response against P. brassicae, researchers then took the sample (HPK4) that showed highest inhibitory action and tested it against proteases of S. littoralis, and found that it also exhibited inhibitory activity making it ideal an ideal candidate for an insecticide (Nath et al., 2015). To test inhibitor ability as an insecticide researchers used cabbage leaf discs coated in trypsin inhibitor extracted from HPK4 seeds as it had the highest activity, and fed it to newly hat ched larvae for 5 days (Nath et al., 2015). The experiment measured the amount of the leaf disc eaten and fecal matter produced from larvae over the 5 day period using different concentrations of trypsin inhibitor ranging from 0.025mg to 2.5mg (Nath et al., 2015).Ãâà It was found that P. brassicae larvae were sensitive to inhibitor as they showed mortality rate ranging from 10% to 80% (at 0.025mg and 2.5mg concentration respectively) after 5 days of feeding (Nath et al., 2015). Larval fecal matter was also noted to having 38% less gut trypsin and other soluble proteins compared to fecal matter in control samples, and with less of cabbage leaf being eaten in all samples compared to control due to massive dying off of larvae (Nath et al., 2015).Ãâà Larval death could be attributed to lack of essential amino acids in insects body due to trypsin inhibitor (Nath et al., 2015). Reduced soluble protein in fecal matter was attributed to less intestinal aberration and the fact th at much less of the leaf was eaten overall (Nath et al., 2015).Ãâà Similar results were found in complementary study regarding the effects on S. littoralis, with low survival rates, reduced larval mass, and decreased soluble protein concentration in fecal matter compared to control (Nath et al., 2015). Overall researchers were able to conclude that the PIs (trypsin inhibitor in this case) from various germinating seed strains were able to inhibit gut proteinases of many lepidopteran larvae such as P. brassicae and S. littoralis (Nath et al., 2015).Ãâà It is worth noting that while this experiment used PIs as a spray over plants, researchers indicate that this holds promising future for crops to express higher levels of proteinase inhibitors naturally to fight pest populations in a way without spraying toxic pesticides (Nath et al., 2015). Another tested method to fight pests was with serine proteinase inhibitors. Mosquitoes are a major vector of disease carrying with them malaria, west nile virus, and etc, mosquitoes are found around the world and it has been reaffirmed many times that the best way to control mosquitos is through controlling populations (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013).Ãâà This topic has been studied extensively and is known that the majority of digestive enzymes for mosquitoes are serine proteases (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). For this experiment researchers looked into Ae. aegypti a mosquito strain which is found commonly around the world (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). It was determined that mosquito larvae would be the ideal target for this protease inhibitors because they are aquatic and feed constantly which would give inhibitors the greatest chance to succeed in killing them as they are in early development (Soares, Soar es Torquato, Alves Lemos, Tanaka, 2013). To determine which serine proteases were present in mosquito larvae researchers performed a kinetic assay of larval midgut proteins and determined that the gut extract was a host to trypsin-like, elastase-like, and chymotrypsin-like enzymatic activities (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). Researchers then used a phage display system to select an inhibitor for all of these digestive proteases, finding that HiTI a trypsin inhibitor from the horn fly would suffice because of successful detection for HiTI on an active M13 phage as it was fused to coat one of the coat proteins (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013).Ãâà Researchers then created aÃâà combinatorial HiTI inhibitor library and tested for their ability to inhibit the serine proteases in mosquito larvae and their ability to inhibit the trypsin-like, chymotrypsin-like and elastase-like proteases (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). Amino acid analysis of phagemid DNA indicated that for HiTI, the largest area for variation occurred in the P1 position of the enzyme (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). This was important because it appeared this position determined the specificity of the HiTI inhibitor, as it was found that if a basic amino acid was present in P1 it would inhibit trypsin, while chymotrypsin would be inhibited if hydrophobic amino acids was present, and if small aliphatic amino acids are present then elastase would be inhibited (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). Among the library created mutants that would inhibit one of the three noted above were found with majority of clones not being proteases (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). Researchers then proceeded to purify and clone the HiTI variants into a plamids which experessed in P.pastoris (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013).It was found that the wild type HiTI was able to inhibit the trypsin-like enzymes but not the remaining two (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). Researchers were able to find 3 mutants that inhibited trypsin-like enzymes but did not inhibit elastase-like and chymotrypsin-like enzymatic reactions, two variants were found to inhibit chymotrypsin with high selectivity for bovine chymotrypsin, one of which (T23) was also found to be an inhibitor for elastase-like proteases as well reaffirming the researchers belief in specific selection by inhibitors for different proteases (Soares, Soares Torquato, Alves Lemos, Tanaka, 2013). The results of this research are promising because this study provides a better understanding of mosquito gut enzymes and provides a framework for insecticide development based on protease inhibitors for mosquitos. In conclusion, it was found that proteinase inhibitors are a viable methods for controlling pests whether it is controlling mosquito populations by feeding larvae serine proteinase inhibitor or coating crops with trypsin inhibitors and feeding it to pests. Much of the work currently has been formed around determining which proteinase inhibitors would match well with their intended target. In order to expand the scope and make proteinases a functional insecticide it would seem more work needs to be done around delivery systems, whether it be as a chemical insecticide spray or genetically altering plants to overexpress proteinase inhibitors. Over time as this field becomes more developed we can be able to determine the effects of these inhibitors on humans. The concept has been proven and more work is needed to make them viable, proteinase inhibitors have a strong future and once the kinks have been worked out then there is no doubt they will be massively successful in increasing crop yields and fighting off pests. References Dantzger, M., Vasconcelos, I. M., Scorsato, V., Aparicio, R., Marangoni, S., Macedo, M. L. R. (2013). Bowman-Birk proteinase inhibitor from Clitoria fairchildiana seeds: Isolation, biochemical properties and insecticidal potential. Phytochemistry, 118(August), 224-235. http://doi.org/10.1016/j.phytochem.2015.08.013 Lin, H., Lin, X., Zhu, J., Yu, X.-Q., Xia, X., Yao, F., You, M. (2017). Characterization and expression profiling of serine protease inhibitors in the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae). BMC Genomics, 18(1), 162. http://doi.org/10.1186/s12864-017-3583-z Nath, A. K., Kumari, R., Sharma, S., Sharma, H. (2015). Biological activity of Dolichos biflorus L. trypsin inhibitor against lepidopteran insect pests. Indian Journal of Experimental Biology, 53(September), 594-599. Soares, T. S., Soares Torquato, R. J., Alves Lemos, F. J., Tanaka, A. S. (2013). Selective inhibitors of digestive enzymes from Aedes aegypti larvae identified by phage display. Insect Biochemistry and Molecular Biology, 43(1), 9-16. http://doi.org/10.1016/j.ibmb.2012.10.007 Broadway, R. M., Duffey, S. S. (1986). Plant proteinase inhibitors: Mechanism of action and effect on the growth and digestive physiology of larval Heliothis zea and Spodoptera exigua. Journal of Insect Physiology, 32(10), 827-833. http://doi.org/10.1016/0022-1910(86)90097-1 Saadati, F., Bandani, A. R. (2011). Effects of Serine Protease Inhibitors on Growth and Development and Digestive Serine Proteinases of the Sunn Pest, Eurygaster integriceps. Journal of Insect Science (Online), 11(72), 72. http://doi.org/10.1673/031.011.7201
Saturday, October 12, 2019
Capital Punishment Essay: Death Penalty Not Consistent with Democracy
Death Penalty Not Consistent with Democracy à Many laws consider a premeditated crime more serious than a crime of pure violence. But what then is capital punishment but the most premeditated of murders, to which no criminal's deed, however calculated it may be, can be compared? For there to be equivalence, the death penalty would have to punish a criminal who had warned his victim of the date at which he would inflict a horrible death on him and who, from that moment onward, had confined him at his mercy for years. à The Council of Europe declares, "The death penalty can no longer be regarded as an acceptable form of punishment from a human rights perspective. It is an arbitrary, discriminatory and irreversible sanction when judicial errors, which can never be entirely ruled out, cannot be reversed." à à à à à à à à à à à à à à à à à à à à à à à In fact, the Council went so far as to create a Protocol No. 6 in 1983, which abolished capital punishment in peacetime. All new member states must ratify this legislation and, so far, 39 of the 41 member states of the council have done so. à à à à à à à à à à à à à à à à à à à à à à à Nonetheless, 17 years after the Council of Europe adopted Protocol No. 6, the United States remains one of the few staunch Western defenders of capital punishment. Both mainstream Presidential candidates in the United States firmly supported the death penalty, and one candidate, George W. Bush, personally signed off on 35 executions in 1999 while governor of Texas. Why has capital punishment, which has been condemned by most Western democracies, continued to have such strong support in the United States? à à à à à à à à à à à à à à à à à à à à à à à à Obviously, Europe and the United States are very different places, but it is ... ...ms cited by the Council as justification for the abolition of capital punishment remain unaddressed in the United States today. Capital punishment is still arbitrary, discriminatory, and irreversible in America. Yet, despite these, and other, compelling reasons to abolish capital punishment, our nation still defends this barbaric, uncivilized and cruel practice. à To many Americans, capital punishment is a quick fix to a national crime problem. We have been willing to overlook the gross injustices of the practice because we have convinced ourselves that it is making America a safer community. Acceptance of this myth must stop. The United States should follow Europe's lead and acknowledge that the administration of capital punishment in this country is an inherently unfair judicial practice. We must demand a moratorium on the death penalty in America now. Ã
Friday, October 11, 2019
Organization Strategy and Structure Essay
By now, it should have been clear that there is no such thing as the one right organization. There are only organizations, each of which has distinct strengths, distinct limitations and specific applications. It has become clear that organization is not an absolute. It is a tool for making people productive in working together. As such, a given organizational structure fits certain tasks in certain conditions and at certain times. Given this perspective, as organizations tend toward more efficiency and effectiveness, so does the structure. For example, one hears a great deal today about ââ¬Å"the end of hierarchy. â⬠This is blatant non-sense. In any institution, there has to be a final authority say, the boss ââ¬â someone who can make the final decision and who can then expect to be obeyed. But, what is the right organization to handle crisis is not the right organization for all tasks. Sometimes the team approach is the right answer. In fact, the pharmaceutical industry used this strategy long before ââ¬Å"teamâ⬠became a buzzword in the organization community.
Thursday, October 10, 2019
Two Business A2 Level Critical Path Analysis Questions
Q1) Discuss the benefits to Balfour Beatty of using critical path analysis in order to plan its construction projects. (15 marks) Critical path analysis identifies the most efficient and cost effective way of completing a complex project. The various activities which together will make up the project are identified, and the order of these activities are identified. Then, the duration of each activity is estimated and these factors are then arranged as a network or graph, showing the whole project from start to finish, and showing which tasks can happen at the same time.The sequence of tasks which have to be done one after another with no gaps in between is called the Critical Path. One benefit of Critical Path analysis to Balfour Beatty is that it always finds the shortest time possible for completing a complex project. ââ¬Å"The customer requested completion in 124 weeks but through careful planning using Critical Path Analysis, Balfour Beatty was able to plan the project for compl etion in 79 weeks. This can give a competitive edge and is an important element of time-based management. If a company is able to complete the task faster than others, it is more likely that they will get chosen, providing the company with more customers, more revenue and therefore more profit. A second benefit of Critical Path Analysis to Balfour Beatty is that it allows managers to operate Just-in-time production. Resources such as raw materials, labour and equipment can be employed right at the earliest start time.Construction companies rely on subcontractors to complete certain tasks and for certain equipment to be hired at specific times, so with Critical Path Analysis, a manager could predict the exact time a certain piece of equipment would be needed and book the particular equipment early on to ensure that the company will have it when needed. This saves on the storage costs and opportunity costs of stock holding, and improves liquidity.Overall, I believe that Critical Path Analysis is a very recommended way of managing time, and will ensure that a Balfour Beatty will use their time in the most productive way possible when using this network, improving efficiency and making customers want to use them again. Q2) Evaluate the main difficulties faced by Balfour Beatty and other construction companies in their use of CPA to plan their projects. (15 marks) Critical path analysis identifies the most efficient and cost effective way of completing a complex project.The various activities which together will make up the project are identified, and the order of these activities are identified. Then, the duration of each activity is estimated and these factors are then arranged as a network or graph, showing the whole project from start to finish, and showing which tasks can happen at the same time. The sequence of tasks which have to be done one after another with no gaps in between is called the Critical Path. One difficulty of using Critical Path Analysis is t hat unless critical activities are identified and supervised closely, thereââ¬â¢ll be delays to the whole project.Critical path analysis puts pressure on mangers to manage effectively and meet deadlines. If, for example, Balfour Beatty was unable to get hold of a particular piece of equipment when needed, the whole project could be delayed by the amount of time that it takes to get the equipment. This means that there will be many employees being paid with no output and the whole project is delayed with doesnââ¬â¢t usually bode well with the customer. A second difficulty of using Critical Path Analysis is that Critical path analysis sets tight deadlines, especially for critical activities.It can be very tempting for the employees to cut corners in order to meet these deadlines, but that can mean quality can suffer. If Balfour Beattyââ¬â¢s employees cut corners with the Bull ring shopping centre, this could mean that the construction was not done properly, causing risks to p ersons entering the shopping centre, or the planning of the bull ring centre may have been rushed, meaning that the layout was not thought out properly, causing problems when it came to construction. Critical Path Analysis puts a lot of pressure on all employees, which could in turn affect the whole project.
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